Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof

摘要

The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T−2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

主权项

1. A poly(organophosphazene)-superparamagnetic nanoparticle complex comprising a biodegradable and thermosensitive phosphazene-based polymer showing a sol-to-gel behavior depending upon the temperature change; and a superparamagnetic ferrite nanoparticle represented by Chemical formula 2a, or Chemical formula 2b:
Fe3+,T(Fe2+,Fe3+)OO42−  Chemical formula 2a Fe3+,T(Me2+,Fe3+)OO42  Chemical formula 2b Wherein, Me is a transitional metal selected from the group consisting of Sc, Ti, V, Cr, Mn, Co, Ni, Cu and Zn, T is tetrahedral site, and O is octahedral site.