Filler composition for tissue reinforcement

摘要

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

主权项

1. A filler composition for tissue augmentation comprising from 1 to 3% (w/w) of a hydrogel of hyaluronic acid cross-linked with an alkylene diamine having the following Formula 1 and from 0.1 to 0.4% (w/w) of an unmodified hyaluronic acid, based on total weight of the composition:
[HA]-C(O)—NH—R1-NH—C(O)-[HA]  [Formula 1] wherein, HA represents hyaluronic acid excluding one carboxyl group or a salt thereof, R1 represents C3-C10 alkylene unsubstituted or substituted with hydroxy, C1-C6 alkyl or C1-C6 alkoxy, and the molecular weight of the hyaluronic acid used in a cross-linking reaction is from 10,000 to 4,000,000 Daltons, and the molecular weight of unmodified hyaluronic acid is from 10,000 to 4,000,000 Daltons.