Peptide tyrosine tyrosine analogues

摘要

Peptide analogues of PYY, compositions comprising said analogues and methods of using said analogues for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for a reduction in appetite, reduction in food intake or reduction of calorie intake in a subject.

主权项

1. An analogue of Peptide Tyrosine Tyrosine (PYY) comprising an amino acid sequence represented by formula (I)(SEQ ID NO: 1)Xaa2-Ile-Xaa4-Pro-Xaa6-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Xaa16-Xaa17-Xaa18-Xaa19-Tyr-Xaa21-Xaa22-Ala-Leu-Xaa25-His-Tyr-Leu-Asn-Xaa30-Val-Thr-Arg-Gln-Arg-Tyr-NH2 (I)wherein
Xaa2 is Pro; Xaa4 is selected from the group consisting of His and Lys; Xaa6 is selected from the group consisting of Asp, Glu, His, Lys, Ser, Thr and Val; Xaa16 is selected from the group consisting of Gln and Glu; Xaa17 is selected from the group consisting of Ile and Leu; Xaa18 is selected from the group consisting of Ala, Asn, Asp and Val; Xaa19 is selected from the group consisting of Arg and His; Xaa21 is selected from the group consisting of His, Phe and Tyr; Xaa22 is selected from the group consisting of Ala and Ile; Xaa25 is selected from the group consisting of Arg, Gln and His; and Xaa30 is His; or an analogue of PYY of formula (I) that has been modified by one or more processes selected from the group consisting of amidation, glycosylation, carbamylation, acylation, sulfation, phosphylation, cyclization, lipidization, and pegylation; or a salt and/or solvate thereof.