METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to organic chemistry, namely to a method for producing methyl 1-[(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-(4-methylphenyl)methyl]cyclohexane carboxylate (I)consisting in the fact that 1-bromcyclohexane carboxylic acid methyl ester is boiled with zinc and 2-(4-methylbenzylidene)-1H-indene-1,3(2H)-dione in the medium of benzol - ethylacelate - hexamethylphosphotriamide (10:5:1) for 8 hours with 67% yield.EFFECT: prepared compound possesses analgesic activity.1 tbl, 2 ex