| 发明名称 |
2-(5-ETHYL-1,3,4-THIADIAZOLYL)AMIDE OF 2-(4-BROMOPHENYL)-4-OXO-4-PHENYL-2-BUTENOIC ACID, HAVING ANALGESIC EFFECT |
| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, novel biologically active substances of the class of N-hetarylamides of 4-aryl-2,4-dioxobutanoic acids, and specifically to 2-(5-ethyl-1,3,4-thiadiazolyl)amide of 2-(4-bromophenyl)-4-oxo-4-phenyl-2-butenoic acid. The compound is obtained by reacting 4-bromophenyl-5-aryl-3-imino-3H-furan-2-one with 2-amino-5-ethyl-1,3,4-thiadiazole with equimolar ratio of reactants in a medium of anhydrous toluene while boiling, followed by separation of the end product.EFFECT: obtaining compounds having analgesic effect, as well as low toxicity1 tbl |
| 申请公布号 |
RU2549572(C2) |
申请公布日期 |
2015.04.27 |
| 申请号 |
RU20130134779 |
申请日期 |
2013.07.23 |
| 申请人 |
GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "PERMSKAJA GOSUDARSTVENNAJA FARMATSEVTICHESKAJA AKADEMIJA" MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII (GBOU VPO PGFA MINZDRAVA ROSSII) |
发明人 |
PULINA NATAL'JA ALEKSEEVNA;KOZHUKHAR' VJACHESLAV JUR'EVICH;KRASNOVA ANASTASIJA IVANOVNA;JUSHKOVA TAT'JANA ALEKSANDROVNA |
| 分类号 |
C07D285/135;A61K31/433;A61P29/00 |
主分类号 |
C07D285/135 |
| 代理机构 |
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