Fused heteroaryls and their uses

摘要

Provided are fused heteroaryls of general formula (1), wherein the variables are as described herein. Examples of the compounds include (S)-1-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-hydroxypropan-1-one and 1-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c][1,5]naphthyridin-1-yl)piperidin-1-yl)-2-methylpropan-1-one. The compounds are inhibitors of phosphoinositide 3-kinases (PI3Ks) and can inhibit mammalian target of rapamycin (mTOR). The compounds may be useful in the treatment of cancer.