摘要 |
Substituted bicyclic beta-lactams of Formula I:
are ²-lactamase inhibitors, wherein a , X, R 1 and R 2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ²-lactam antibiotics. In particular, the compounds can be employed with a ²-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to ²-lactam antibiotics due to the presence of the ²-lactamases. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BLIZZARD, TIMOTHY A.;CHEN, HELEN;GUDE, CANDIDO;HERMES, JEFFREY D.;IMBRIGLIO, JASON E.;KIM, SEONGKON;WU, JANE Y.;HA, SOOKHEE;MORTKO, CHRISTOPHER J.;MANGION, IAN;RIVERA, NELO;RUCK, REBECCA T.;SHEVLIN, MICHAEL |