| 摘要 |
A carrier composition for delivery of a biologically active compound comprising: about 0.01%w/w to about 20%w/w of a phosphate compound of an electron transfer agent selected from the group consisting of mono-(tocopheryl) phosphate, mono-(tocopheryl) phosphate monosodium salt, mono-(tocopheryl) phosphate disodium salt, di-(tocopheryl) phosphate, di-(tocopheryl) phosphate monosodium salt, or a mixture thereof; about 0.05%w/w to about 20%w/w of a solvent selected from the group consisting of, N-dimethyl-formamide (DMF), N-methyl-2-pyrrolidone (NMP), dimethylsulfoxide (DMSO), N,N-dimethylacetamide (DMAC), dioxane hexamethylphosphorotriamide, propylene carbonate, gamma-butyrolacetone, monomethyl ether acetate, ethyl lactate, 1,3 dimethyl-2- imidazolidinone (dimethyl isosorbide, or DMI), propylene glycol ricinoleate, isononyl isononanoate and sucrose esters of fatty acids, sopropyl myristate, isopropyl palmitate, isopropyl isostearate, diisopropyl adipate, diisopropyl dimerate, maleated soybean oil, octyl palmitate, cetyl lactate, glycerine, caprylyl glycol, squalene, bisabolol, benzylalcohol, cetyl ricinoleate, cetyl acetate, wheat germ lycerides, myristyl lactate, decyl oleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, octyl dodecanol, and octyl hydroxystearate; about 0%w/w to about 5%w/w of one or more excipients; a balance of water. Also disclosed is a process for making the carrier and the use of the carrier in formulations comprising lidocaine, diclofenac, ketoralac, prilocaine, halobetasol or hydrocortisol. |
