Pharmaceutical compositions of tenecteplase

摘要

Disclosed is a pharmaceutical composition as an intravenous bolus injection for treatment of acute ischemic stroke in human subjects comprising: a. an effective and safe amount of tenecteplase, which is prepared by a perfusion based continuous fermentation process; b. a pharmaceutically acceptable inorganic buffer; c. pharmaceutically acceptable stabilising agents; and d. optionally, a pharmaceutically acceptable carrier.