发明名称 |
METHOD OF OBTAINING THERMOSTABLE DRIED VACCINE FORMULATIONS |
摘要 |
This present invention relates to compositions and methods for stabilizing a dried vaccine formulations. In particular, the invention provides a method for producing a vaccine composition comprising the steps of providing an aqueous composition comprising a buffer, the vaccine components and between 17.5% w/w and 60% w/w of a non-polymeric sugar, freezing the composition, and applying microwave radiation under a pressure lower than atmospheric pressure in order to sublimate the composition and obtain a dried vaccine formulation. The invention also provides a product obtainable by this method. |
申请公布号 |
CA2927434(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
CA20142927434 |
申请日期 |
2014.10.13 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BHAMBHANI, AKHILESH;EVANS, ROBERT K.;SINACOLA, JESSICA;JONES, MORRISA |
分类号 |
A61K9/00;A61K39/12;A61K47/26 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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