| 发明名称 |
Substrate Mediated Enzymes Prodrug Therapy |
| 摘要 |
A method is provided for administering an active drug agent to cells adhering and/or adjacent to a substrate, said substrate comprising one or more immobilized enzymes, which are capable of converting an inert prodrug into an active drug agent, said method comprising providing at least one inactive prodrug to said substrate. Also a kit is provided which comprise a substrate comprising one or more immobilized enzymes capable of converting an inert prodrug into an active drug agent, and at least one inert prodrug. A stent is also provided, which comprise a substrate comprising one or more immobilized enzymes capable of converting an inert prodrug into an active drug agent. |
| 申请公布号 |
US2015110847(A1) |
申请公布日期 |
2015.04.23 |
| 申请号 |
US201314401980 |
申请日期 |
2013.05.21 |
| 申请人 |
Aarhus Universitet |
发明人 |
Zelikin Alexander;Kristensen Betina Fejerskov |
| 分类号 |
A61L31/14;A61L31/04;A61L27/16;A61L27/52;A61L27/34;A61K31/7048;A61L31/10 |
主分类号 |
A61L31/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of administering at least one active drug agent to cells adhering and/or adjacent to a substrate, said substrate comprising one or more immobilized enzymes, which are capable of converting an inert prodrug into an active drug agent, said method comprising providing at least one inactive prodrug to said substrate. |
| 地址 |
Aarhus C DK |
