| 摘要 |
The present invention relates to a composition for inducing the differentiation of osteoclasts, containing progranulin as an active ingredient, or a composition for preventing or treating osteoporosis, containing a progranulin inhibitor as an active ingredient. More specifically, the progranulin serves as an RANK-dependent cell signal factor (cell-communication factor), and as a mediating factor in osteoporosis through the induction of inflammation. It has been confirmed that a remarkably high concentration of progranulin exists in the serum of prostate cancer patients, osteoporosis patients, and patients who have reduced bone density due to lying in bed for a long time, compared to control groups. Accordingly, the progranulin can be used as an osteoclast differentiation factor and a biomarker for osteoporosis or metastatic prostate cancer. |
