HUMAN MONOCLONAL ANTIBODIES AGAINST THE MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV) AND ENGINEERED BISPECIFIC FUSIONS WITH INHIBITORY PEPTIDES

摘要

The invention provides polypeptides (e.g., antibodies) and fusion proteins that target a epitope in the receptor binding domain (RBD) of the spike (S) glycoprotein of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The polypeptides and fusion proteins can be used to treat and prevent MERS-CoV infection in mammals.