| 主权项 |
1. A compound of Formula (I″) or Formula (A″): wherein: R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —COR2, —COOR3, or —CONR4R5; z is 0, 1, 2, or 3; each instance of R3a is independently hydrogen, alkyl, alkenyl, alkynyl, alkoxyl, halogen, cyano, amino, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; B is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —COR2, —COOR3, —CONR4R5, or —Si(R6)3;
wherein R2, R3, R4, R5, and R6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R1c is hydrogen, alkyl, alkenyl, or alkynyl; R2c is hydrogen, alkyl, alkenyl, or alkynyl; Wd is heteroaryl, cycloalkyl, heterocycloalkyl, or aryl; and X is CR1a or N;
wherein R1a is hydrogen, halo, alkyl, alkenyl, alkynyl, or CN;wherein each alkyl, alkenyl, or alkynyl is optionally substituted with one or more halo, OH, alkoxy, NH2, NH(alkyl), N(alkyl)2, COH, CO(alkyl), COOH, COO(alkyl), CONH2, CONH(alkyl), CON(alkyl)2, S(O)(alkyl), S(O)2(alkyl), cycloalkyl, heterocycloalkyl, aryl or heteroaryl;wherein each cycloalkyl, heterocycloalkyl, aryl or heteroaryl is optionally substituted with one or more halo, alkyl, alkenyl, alkynyl, OH, alkoxy, oxo, NH2, NH(alkyl), N(alkyl)2, COH, CO(alkyl), COOH, COO(alkyl), CONH2, CONH(alkyl), CON(alkyl)2, S(O)(alkyl), or S(O)2(alkyl);wherein in Formula (I″), when X is CH, B is unsubstituted phenyl, and Wd is then R1 is not hydrogen, CH2Si(CH3)3, methyl, (CH2)NH2, (CH2)2NH2, (CH2)NHSO2CH3, or (CH2)—NHC(O)R1x; n is 1 or 2; R1x is methyl, C2 alkenyl, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl, where the alkenyl, cyclohexyl, cyclopentyl, tetrahydrofuranyl, furanyl, or pyrrolidinyl is optionally substituted with one or two groups independently selected from oxo and cyano;wherein in Formula (A″), when X is CH, B is unsubstituted phenyl, and Wd is then R1 is not phenyl; or a pharmaceutically acceptable form thereof. |
