| 摘要 |
<p>A long-lasting, sustained-release micropellet and a preparation method therefor are disclosed. A long-lasting trimetazidine hydrochloride sustained-release micropellet comprises, from the inside outward, a drug-containing pellet core, a sustained-release coating layer, and, optionally, an isolation coating layer provided between the core and the sustained-release coating. The mass weight of the isolation coating layer is 0-15% of that of the core, the mass weight of the sustained-release coating layer is 5-30% of that of the core, and the sustained-release coating layer contains a gastrointestinal tract adhesive. The trimetazidine hydrochloride sustained-release micropellet of the present invention is prescription-designed, using sustained-release coating material to encapsulate uniformly a drug-containing core, thus allowing the drug-release effects of the micropellet to be sustained, slow, and uniform. This reduces the release rate of active components and delays the peak time, such that release occurs steadily and continuously over 24 hours and plasma concentration stability is maintained, thereby avoiding the possibility of insufficient plasma concentration during morning ischemia. This also reduces the dosage rate to once per day, which promotes an increase in patient compliance.</p> |
