发明名称 METHOD AND APPARATUS FOR DELIVERY OF A MEASURED DOSAGE OF A NON-AEROSOL, NON-SPRAY FOAM COMPOSITION OF MINOXIDIL
摘要 A non-pressurized container that contains one or more of: a foamable composition of minoxidil, or a pharmaceutically acceptable salt thereof, and a dihydrotestosterone blocker in a formulation with a precise density and viscosity to yield a foam with a temperature sensitivity and shear strength designed for inverted application and immediate targeted release at body temperature under a minimal hand applied pressure to the scalp.
申请公布号 US2015111913(A1) 申请公布日期 2015.04.23
申请号 US201414588108 申请日期 2014.12.31
申请人 Maniga Nyangenya 发明人 Maniga Nyangenya
分类号 A61K8/49;B05B11/00;A61K8/04;A61K8/60;A61Q7/00 主分类号 A61K8/49
代理机构 代理人
主权项 1. A method for delivering a liquid as a foam for the treatment and prevention of hair loss of a human user, said method comprising the steps of: providing a liquid formulation comprising: a first hair growth constituent comprising a minoxidil concentration of one-tenth to four percent by weighta first hair loss blocker comprising a cetearyl glucoside concentration of one-tenth to one percent by weight;a second hair loss blocker comprising a 8-hydroxyquinoline sulfate concentration of 0.001 to 0.4 percent by weightlactic acid, andwater; adjusting said liquid formulation to comprise a first formulation specification range of a formulation viscosity within one-half of one percent of that of water viscosity at standard temperature and pressure, wherein said formulation viscosity is less than said water viscosity; after preparation of said liquid formulation, adjusting said liquid formulation to a second formulation specification range of a density of 0.995±0.005% g/mL to form a foamable formulation; packaging said foamable formulation in a non-aerosol delivery container comprising a calibrated pump delivery volume, said step of packaging occurring prior to evaporation of at least one of an alcohol and an ether of said liquid formulation moving said foamable formulation out of at least one of said first formulation specification range and said second formulation specification range; pumping said non-aerosol delivery container to force a measured pump volume of said foamable formulation through a screen to form a foam at room temperature, said formulation viscosity yielding a substantially uniform and self-adhering froth under pressures resultant from manual actuation of said measured pump volume while failing to form a uniform froth under shear forces from an aerosol delivery system, said step of pumping delivering said foam to a palm of the user; said foam forming a liquid layer trapped between said foam and the palm, said liquid layer comprising less than twenty percent of the volume of said foam; inverting said palm to deliver the foam and the liquid layer to a targeted scalp location, said liquid layer substantially trapped between the inverted palm and the foam until at least one of: delivery to said scalp and at least sixty seconds; and upon substantial contact of the inverted palm and the scalp, the foam substantially dissipating within five seconds at surface body temperature of 33-37° C. to substantially deliver said minoxidil to a targeted area without any of: running off of the scalp and being dissipated by air currents.
地址 Gilbert AZ US