| 发明名称 |
DERIVATIVES OF AVICIN D AND METHODS OF MAKING AND USING THEREOF |
| 摘要 |
Disclosed herein are novel oxetane derivatives of avicin D, including compounds of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives and compositions thereof, including for the treatment of cancer, are also provided. |
| 申请公布号 |
US2015111843(A1) |
申请公布日期 |
2015.04.23 |
| 申请号 |
US201314380594 |
申请日期 |
2013.02.22 |
| 申请人 |
HARIDAS Valsala;GUTTERMAN Jordan;PARKER David L. |
发明人 |
Michels Peter C.;Khmelnitsky Yuri L.;Gutterman Jordan;Haridas Valsala;Mozhaev Vadim M. |
| 分类号 |
C07H15/24 |
主分类号 |
C07H15/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of the formula:wherein:
n is 0-3, and R is —H or —OH;or a pharmaceutically acceptable salt, acetal, ketal or tautomer thereof. |
| 地址 |
US |
