发明名称 |
Bispecific SCFV Immunofusion (BIF) |
摘要 |
Certain embodiments are directed to a bispecific immunoglobulin that is capable of binding cell surface molecules on a target cell, such as cancer cells, and cell surface molecules on immune effector cell, such as cytotoxic T lymphocytes, resulting in the targeted killing of target cells. In certain aspects a Bif is a polypeptide comprising a first target binding domain that specifically binds a cancer cell, a second effector binding domain that specifically binds an immunologic effector, and an immunoglobulin constant region linker operatively coupling the first and second binding domain. |
申请公布号 |
US2015110789(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
US201314402009 |
申请日期 |
2013.05.18 |
申请人 |
Scott & White Healthcare |
发明人 |
Liu Jen-Sing;Kuo Shu-Ru |
分类号 |
C07K16/30;C07K16/28 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
1. A polypeptide comprising a first target binding domain that specifically binds a cancer cell, a second effector binding domain that specifically binds an immunologic effector, and an immunoglobulin constant region linker operatively coupling the first and second binding domain. |
地址 |
Temple TX US |