ACTIVATORS OF HUMAN PYRUVATE KINASE

摘要

PROBLEM TO BE SOLVED: To provide pyruvate kinase M2 activators that are useful in treating cancer and anemia.SOLUTION: Disclosed are bis-sulfonamide piperazinyl compounds represented by formula (I) or pharmaceutically acceptable salts thereof. [In the formula, L is a linker including an amino group, and Rand Rare aryl or heteroaryl, with the provisos that Rand Rare not dimethoxyphenyl and Rand Rare not both 4-methylphenyl simultaneously.]