COATINGS CONTAINING MULTIPLE DRUGS

摘要

A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

主权项

1. A method of depositing a coating on a substrate comprising:
a. providing a substrate; b. depositing on said substrate a first layer comprising a first pharmaceutical agent in dry powder form without use of a solvent; c. depositing a second layer in dry powder form without use of a solvent, the second layer comprising a second pharmaceutical agent; d. depositing one or more polymer layers thereby forming a coating; and then e. sintering said coating under conditions that do not substantially modify a morphology of said pharmaceutical agents, wherein said sintering comprises treating the coated substrate with a compressed gas, compressed liquid, or super critical fluid that is a non-solvent for both the polymer and pharmaceutical agents; wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents and at least one of said first and second pharmaceutical agents comprises the morphology that is crystalline or semi-crystalline.