Transdermal Therapeutic System For Administering Rivastigmine Or Derivatives Thereof

摘要

The present invention relates to a transdermal therapeutic system for administering an active substance through the skin, comprising:
a) a cover layer,b) a reservoir present on the cover layer, comprising a polymer matrix comprising the active substance,c) an adhesive layer present on the reservoir comprising a contact adhesive, andd) a removable layer present on the adhesive layer,

the active substance being rivastigmine, a physiologically compatible salt, hydrate, solvate or derivative thereof,

characterized in that the polymer matrix of the reservoir comprises neither hydroxyl groups nor carboxyl groups.

主权项

1. A method for preparing a transdermal therapeutic system containing rivastigmine, comprising embedding the rivastigmine or a physiologically compatible salt, hydrate, solvate or derivative thereof in a polymer matrix comprising a polymer and/or copolymer or mixture thereof, wherein said polymer and/or copolymer or mixture thereof contains essentially neither free hydroxyl groups nor free carboxyl groups.