发明名称 |
DRUG CONJUGATE COMPRISING DRUG LINKED TO HUMAN C-MET ANTIBODY, AND USE THEREFOR |
摘要 |
The present invention relates to a drug conjugate comprising a cytotoxic drug conjugated to a c-Met specific human antibody. More specifically, the present invention relates to: a drug conjugate comprising a cytotoxic drug conjugated to a c-Met specific human antibody; a pharmaceutical composition for cancer treatment comprising the drug conjugate; and a cancer treatment method comprising a step in which the drug conjugate or pharmaceutical composition is administered to an individual. |
申请公布号 |
US2015110815(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
US201214360937 |
申请日期 |
2012.11.28 |
申请人 |
Korea Research Institute of Bioscience and Biotechnology ;A & R Therapeutics Co., Ltd. |
发明人 |
Park Young Woo;Jo Ki Won;Jo Sun Jeong;Hyun Soon Sil;Park Jae Eun;Yoo Seok Ho;Jang Myeoung Hee;Kim Hye Nan;Park Chan Woong |
分类号 |
A61K47/48;A61K31/704;C07K16/28 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. An antibody-drug conjugate comprising a cytotoxic drug conjugated to a c-Met-specific human antibody, wherein the antibody comprises:
a heavy-chain variable region comprising: i) a heavy-chain CDR1 comprising amino acids having the sequence set forth SEQ ID NO: 1; ii) a heavy-chain CDR2 comprising amino acids having the sequence set forth in SEQ ID NO: 2; and iii) a heavy-chain CDR3 comprising amino acids having the sequence set forth in SEQ ID NO: 3; and a light-chain variable region comprising: i) a light-chain CDR1 comprising amino acids having the sequence set forth in SEQ ID NO: 4; ii) a light-chain CDR2 comprising amino acids having the sequence set forth in SEQ ID NO: 5; and iii) a light-chain CDR3 comprising amino acids having the sequence set forth in SEQ ID NO: 6. |
地址 |
Daejeon KR |