发明名称 |
Modulator Compounds of Drug Resistance in Epithelial Tumor Cells |
摘要 |
The described invention provides a method of treating a patient with an epithelial cancer comprising administering a composition comprising a therapeutic amount of an inhibitor of a BTK protein and one or more chemotherapeutic agent(s) selected from the group consisting of an antimetabolite, a platinum coordination compound, an alkylating agent and a combination thereof, wherein the composition is effective to reduce one or more of tumor cell growth, tumor cell clonogenicity, tumor cell proliferation, tumor cell viability and tumor volume and the therapeutic amount of the inhibitor of a BTK protein and the one or more chemotherapeutic agent(s) exerts a synergistic effect. The described invention also provides methods of treating a chemotherapy drug-resistant cancer and sensitizing a cancer patient to chemotherapy. |
申请公布号 |
US2015111953(A1) |
申请公布日期 |
2015.04.23 |
申请号 |
US201414586051 |
申请日期 |
2014.12.30 |
申请人 |
Lavitrano Marialuisa;Grassilli Emanuela;Helin Kristian |
发明人 |
Lavitrano Marialuisa;Grassilli Emanuela;Helin Kristian |
分类号 |
A61K31/519;A61K45/06;A61K31/513 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a patient with an epithelial cancer comprising administering a composition comprising a therapeutic amount of an inhibitor of a BTK protein and one or more chemotherapeutic agent(s) selected from the group consisting of an antimetabolite, a platinum coordination compound, an alkylating agent and a combination thereof, wherein the composition is effective to reduce one or more of tumor cell growth, tumor cell clonogenicity, tumor cell proliferation, tumor cell viability and tumor volume and the therapeutic amount of the inhibitor of a BTK protein and the one or more chemotherapeutic agent(s) exerts a synergistic effect. |
地址 |
Milano IT |