| 发明名称 |
OPTICAL REGULATION OF GENE EXPRESSION IN THE RETINA |
| 摘要 |
The present invention provides methods and compositions for regulating transgene expression in a subject using heat generated by electro-magnetic radiation in a target cell. The heat is generated by a thermo generator resided in the target cell upon application the electromagnetic radiation. The amount of the heat is controlled by the energy delivered by the electromagnetic radiation. |
| 申请公布号 |
US2015111275(A1) |
申请公布日期 |
2015.04.23 |
| 申请号 |
US201314407054 |
申请日期 |
2013.06.10 |
| 申请人 |
Palanker Daniel V.;Chalbert, JR. Thomas W. |
发明人 |
Palanker Daniel V.;Chalbert, JR. Thomas W. |
| 分类号 |
A61K48/00;A61K41/00;A61F9/008;C12N15/86 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for modulating gene expression in a subject, comprising;
(a) expressing a transgene in a plurality of cells in a subject, wherein said plurality of cells comprises a target cell, wherein said target cell comprises; (i) a polynucleotide encoding said transgene; and (ii) a thermo generator capable of generating heat upon application of an electromagnetic radiation; and (b) applying said electromagnetic radiation to said target cell to destroy said target cell, thereby modulating expression of said transgene in said subject. |
| 地址 |
Sunnyvale CA US |
