SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS

摘要

The invention provides a compound of Formula (I);;or a pharmaceutically acceptable salt thereof; wherein

G is
;;R1, R2 and R3 areas described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

主权项

1. A compound of Formula (I)or a pharmaceutically acceptable salt thereof, wherein
G is R1 is a (C1-C6)alkyl or (C3-C7) cycloalkyl; R2 is indolyl, indazolyl, pyrrolopyridinyl, pyrazolopyridinyl, quinolinyl or benzoimidazolyl; wherein each R2 group is optionally substituted with one to two substituents independently selected from a cyano, -L-C(O)NR4R5, -L-NR4R5, (C1-C3)alkyl, (C1-C3)alkoxy and halo; R3 is hydrogen or (C1-C3)alkyl; L is a direct bond or —X(C1-C3)alkylene; X is a direct bond, O or S; R4 and R5 are each independently hydrogen, (C1-C3)alkyl, (C3-C7)cycloalkyl or four to seven membered heterocyclyl wherein said (C1-C3)alkyl, (C3-C7)cycloalkyl or four to seven membered heterocyclyl is optionally substituted with one to three fluoro or (Cr C3)alkoxy.