发明名称 Method for Producing Recombinant 11-De-O-Methyltomaymycin
摘要 The present invention provides a tomaymycin biosynthetic gene cluster of Streptomyces species FH6421, and its use for producing 11-de-O-methyltomaymycin.
申请公布号 US2015111298(A1) 申请公布日期 2015.04.23
申请号 US201314401109 申请日期 2013.05.13
申请人 Sanofi 发明人 Lattemann Claus;Broenstrup Mark;Werner Stefan;Müller Rolf;Harmrols Kirsten
分类号 C12N15/76;C07K14/36 主分类号 C12N15/76
代理机构 代理人
主权项 1. A nucleic acid molecule comprising at least one nucleic acid selected from the group consisting of: (a) a nucleic acid comprising at least one of the Open Reading Frames (ORFs) 1 to 19 of SEQ ID NO: 2 that encodes proteins of SEQ ID NOs: 4 to 22 or a variant or fragment thereof, whereby the variant or fragment encodes a functionally active variant or fragment of a protein of SEQ ID NOs: 4 to 22, (b) a nucleic acid encoding at least one of the proteins of SEQ ID NOs: 4 to 22 or a functionally active variant or fragment thereof, (c) a nucleic acid encoding a protein that is at least 70%, 80%, 90%, 95% or 97% identical in amino acid sequence to a protein or fragment thereof encoded by the nucleic acid of (a) or (b), (d) a nucleic acid that hybridizes under stringent conditions with a nucleic acid of (a) to (c), (e) a nucleic acid that is complementary to a nucleic acid of (a) to (d).
地址 Paris FR