HUMAN ANTIBODIES TO GFR ALPHA 3 AND METHODS OF USE THEREOF

摘要

The present invention provides antibodies that bind to human GFRα3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GFRα3. The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more GFRα3 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.

主权项

1. A method for treating a GFRα3-related condition or disease, or the pain associated with the GFRα3-related condition or disease, the method comprising administering an isolated monoclonal antibody or antigen-binding fragment thereof that specifically binds to glial cell-line derived neurotrophic factor (GDNF) family receptor alpha 3 (GFRα3), or a composition comprising the antibody or antigen-binding fragment thereof, to a patient in need thereof, wherein the antibody comprises:
(a) a heavy chain complementarity determining region (HCDR) 1 domain of SEQ ID NO: 148; (b) a HCDR2 domain of SEQ ID NO: 150; (c) a HCDR3 domain of SEQ ID NO: 152; (d) a light chain complementarity determining region (LCDR) 1 domain of SEQ ID NO: 156; (e) a LCDR2 domain of SEQ ID NO: 158; and (f) a LCDR3 domain of SEQ ID NO: 160; wherein the GFRα3-related condition or disease is prevented, ameliorated, or reduced in severity or frequency of occurrence, or the pain associated with the condition or disease is prevented, ameliorated, or reduced in severity or frequency of occurrence.