摘要 |
The present invention relates to a glycoprotein comprising a glycan of the formula (102), wherein b is 0 or 1, wherein the core GlcNAcresidue of said glycan is optionally fucosylated, wherein Su(A)x is a sugar derivative comprising x functional groups A wherein x is 1, 2, 3 or 4 and A is independently selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group. (Formula (102)), The invention further relates to a protein-conjugate wherein a modified glycoprotein according to the invention is conjugated to a molecule of interest. Said molecule of interest may for example be an active substance. The invention further relates to a process for the preparation of a modified glycoprotein according to the invention, and to a method for the preparation of a protein-conjugate according to the invention. The invention particularly relates to modified antibodies, antibody-conjugates, antibody-drug conjugates (ADCs) and methods for the preparation thereof. |