发明名称 |
METHODS FOR PREPARING VESICLES AND FORMULATIONS PRODUCED THEREFROM |
摘要 |
The present disclosure provides methods for preparing vesicles. In one aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding the molten mixture of vesicle-forming lipids to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed, wherein in the step of adding the molten mixture of vesicle forming lipids is at a temperature of less than 120° C. In another aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding an aqueous solution comprising an antigen to the molten mixture of vesicle-forming lipids such that antigen-containing vesicles are formed, wherein the resulting mixture is placed under temperature-controlled conditions of less than 60° C. In yet another aspect, the methods involve providing a solution of vesicle forming lipids and adding the solution of vesicle-forming lipids to an aqueous solution comprising an antigen by injection such that antigen-containing vesicles are formed. |
申请公布号 |
EP2663288(A4) |
申请公布日期 |
2015.04.22 |
申请号 |
EP20120733900 |
申请日期 |
2012.01.13 |
申请人 |
VARIATION BIOTECHNOLOGIES INC. |
发明人 |
ANDERSON, DAVID, E.;PERRIE, YVONNE;WILKHU, JITINDER SINGH;KIRCHMEIER, MARC |
分类号 |
A61K9/127;A61K9/10;A61K9/19;A61K31/145;A61K39/00;A61K39/12;A61K39/145;C12N1/04;C12N9/98 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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