发明名称 |
NEURONAL DIFFERENTIATION PROMOTER |
摘要 |
The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the present invention provides a method of promoting neuronal differentiation of neural stem cells, which includes cultivating neural stem cells in the presence of a p38 inhibitor. Neural stem cells are gliogenic or neurogenic. The p38 inhibitor is a nucleic acid which hybridizes to DNA or mRNA encoding p38 under physiological conditions, thereby inhibiting the transcription and/or translation thereof, an expression vector of the nucleic acid, a low molecular p38 inhibitor and the like. |
申请公布号 |
EP2843049(A4) |
申请公布日期 |
2015.04.22 |
申请号 |
EP20130781077 |
申请日期 |
2013.04.26 |
申请人 |
KEIO UNIVERSITY |
发明人 |
KANEDA, HAYATO;OKANO, HIDEYUKI;SHIMAZAKI, TAKUYA |
分类号 |
C12N15/09;A61K31/4439;A61K31/7088;A61K31/7105;A61K35/76;A61K45/00;A61K48/00;A61P25/00;A61P25/14;A61P25/28;A61P43/00;C12N5/0797;C12N5/10;C12N15/113 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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