| 发明名称 |
TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS |
| 摘要 |
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure. |
| 申请公布号 |
EP2861568(A2) |
申请公布日期 |
2015.04.22 |
| 申请号 |
EP20130723783 |
申请日期 |
2013.05.17 |
| 申请人 |
UNIVERSITETET I OSLO |
发明人 |
TASKEN, KJETIL;LYGREN, BIRGITTE;ØSTENSEN, ELLEN;KLAVENESS, JO |
| 分类号 |
C07D277/56;A61K31/135;A61K31/343;A61K31/41;A61K31/426;A61K31/4409;A61P9/00;C07C211/27;C07C211/29;C07C211/44;C07D213/36;C07D257/04;C07D307/79 |
主分类号 |
C07D277/56 |
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