Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs

摘要

The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

主权项

1. A method for providing a protective effect against symptoms of PCV2 infection comprising administering to a pig a single efficacious dose of an immunogenic composition comprising at least 2 μg of recombinant PCV2 ORF2 protein and at least one further component selected from the group consisting of inactivated viral vector, viral inactivators, neutralization agents for viral inactivators, and combinations thereof such that a protective effect against lymphadenopathy in combination with at least one symptom selected from the group consisting of: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders selected from the group consisting of abortion, stillbirths, mummies in pigs, and (7) combinations thereof, is provided after the single dose of the immunogenic composition in comparison to pigs not receiving the immunogenic composition.