High drug load tablet

摘要

The present invention pertains to a high drug load tablet comprising an active ingredient Compound I of formula;
or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.

主权项

1. A small tablet comprising a pharmacologically effective amount of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula (1) in the form of a monomesylate salt as the sole active drug: in an amount from 30% to 80% by weight of the active moiety based on the total weight of the small tablet; and 10 to 35% by weight of at least one disintegrant based on the weight of the small tablet, wherein the at least one disintegrant is cross-linked polyvinlypyrrolidinone, wherein the small tablet is either a small ovaloid tablet that is 10 to 20 mm in length, 5 to 10 mm in width and 4 to 8 mm in thickness or a small round tablet that is 5 to 15 mm in diameter and 2 to 5 mm in thickness and wherein the pharmacologically effective amount of the sole active moiety 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide is from 50 mg to 600 mg.