Efficient processes for large scale preparation of phosphaplatins antitumor agents

摘要

An efficient process for synthesizing phosphaplatins in large quantities is disclosed by adding platinum complex to a concentrated pyrophosphate solution at pH from between about 6.0 to 8.5. After stirring, the temperature and pH are lowered to precipitate out desired phosphaplatins. Particularly, the disclosed processes reduce the need to use large volumes of starting materials, and shorten the reaction time. In addition, disclosed is a process for recycling un-reacted materials from a first phosphaplatins synthesis.

主权项

1. A process for synthesizing phosphaplatins, comprising: concentrating pyrophosphate ligand in a reaction mixture having a pH at approximately 6 to 8.5; and adding platinum complex to the reaction mixture.