| 发明名称 | Method for producing platelets from megakaryocytes | ||
| 摘要 | The present invention relates to a method for producing platelets from mature megakaryocytes. More particularly, the invention relates to an ex vivo method for producing platelets, from mature megakaryocytes, said method comprising a step of subjecting a suspension of mature megakaryocytes to a flow having a minimal shear rate of 600 s−1 on a solid phase coated with Von Willebrand factor. | ||
| 申请公布号 | US9012221(B2) | 申请公布日期 | 2015.04.21 |
| 申请号 | US200913132527 | 申请日期 | 2009.12.04 |
| 申请人 | INSERM (Institut National de la Sante et de la Recherche Medicale);Universite Paris Descartes;Assistance Publique Hopitaux de Paris;Universite de Versailles Saint-Quentin-en-Yvelines | 发明人 | Baruch Dominique;Cramer-Borde Elisabeth;Dunois Claire |
| 分类号 | C12N5/078;A61K35/12 | 主分类号 | C12N5/078 |
| 代理机构 | McAndrews, Held & Malloy Ltd. | 代理人 | McAndrews, Held & Malloy Ltd. |
| 主权项 | 1. An ex vivo method for producing platelets, comprising a step of subjecting a suspension of cells comprising mature megakaryocytes to a flow permitting exposure to a shear rate sufficient for platelet generation, on a solid phase coated with Von Willebrand factor (VWF) or a fragment or variant thereof which binds to GPIb thereby forming platelets. | ||
| 地址 | Paris FR | ||