发明名称 Anti-FAP antibodies and methods of use
摘要 The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
申请公布号 US9011847(B2) 申请公布日期 2015.04.21
申请号 US201113205743 申请日期 2011.08.09
申请人 Roche Glycart, AG 发明人 Bacac Marina;Freimoser-Grundschober Anne;Hosse Ralf;Klein Christian;Moessner Ekkehard;Nicolini Valeria G.;Umaña Pablo
分类号 A61K39/395;C07K16/40 主分类号 A61K39/395
代理机构 代理人 Ropp Traci H.
主权项 1. An antibody that specifically binds to Fibroblast Activation Protein (FAP), wherein said antibody comprises a (a) heavy chain CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 13, and SEQ ID NO: 23; (b) heavy chain CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 47, SEQ ID NO: 81, and SEQ ID NO: 113; (c) heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 135; (d) light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 143; (e) light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 151and; (f) light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 163.
地址 Schlieren CH