Surface plasmon resonance detection system

摘要

A system for detecting the presence of an analyte in a moving substrate or sample handling device is disclosed, providing means (26,30) for integrated triggering of data acquisition with a detector means (28) and data acquisition with a detector means (28). In particular, a surface Plasmon resonance “lab on disk” reader system is disclosed.

主权项

1. A system for detecting changes in Surface Plasmon Resonance indicative of the presence of an analyte in a sample on a substrate, the substrate having a detection portion arranged to receive incident optical radiation for interaction with a detection surface of the detection portion when the sample is present in the detection portion, the system comprising:
a source disposed to illuminate a portion of the substrate with optical radiation, the source being arranged to cause surface plasmon resonance at the detection surface when the sample is present in the detection portion; a detector arrangement disposed to receive optical radiation received from the illuminated portion of the substrate; a driving arrangement arranged to couple to the substrate and move one of the source and the substrate relative to the other, such that the illuminated portion moves over the substrate to the detection portion; a processor coupled to the detector arrangement, the processor being configured to:
generate a trigger signal indicative of Surface Plasmon Resonance occurring in the illuminated portion; andacquire data from the detector arrangement in response to the trigger signal, wherein a change in local refractive index at the detection surface is determinable from the data.