Implantable tizanidine compositions and methods of treatment thereof

摘要

A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of tizanidine to the subject for a long period of time (e.g., one month or one year). The drug delivery composition may include a rate-controlling excipient (e.g., an elastomeric polymer) defining a reservoir containing at least one discrete solid dosage form (e.g., one or more pellets), which includes tizanidine free base and optionally, a sorption enhancer.

主权项

1. A method of treating one or more symptoms of spasticity comprising:
implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of tizanidine to the subject for a period of time of at least one month, wherein the drug delivery composition comprises at least one discrete solid dosage form comprising tizanidine free base surrounded by a drug elution rate-controlling excipient comprising at least one elastomeric polymer defining a reservoir, wherein the elastomeric polymer comprises a polyether polyurethane.