| 发明名称 |
Composition and method for neuroprotection against excitotoxic injury |
| 摘要 |
The present invention discloses the combined treatment of memantine (N-methyl-D-aspartate receptor antagonist) and tea polyphenol (an antioxidant and anti-inflammatory agent) is more effective (synergistic) in neuroprotection than either memantine or tea polyphenol alone in mouse excitotoxic injury. These findings provide useful information about the potential application of memantine and tea polyphenols in preventing or treating clinical excitotoxic injury such as brain trauma, brain ischemia, epilepsy, and Alzheimer's disease. |
| 申请公布号 |
US9011945(B2) |
申请公布日期 |
2015.04.21 |
| 申请号 |
US201314095388 |
申请日期 |
2013.12.03 |
| 申请人 |
National Taiwan University |
发明人 |
Lin-Shiau Shoei-Yn;Lin Jen-Kun |
| 分类号 |
A61K36/82;A61K36/185;A61K31/353;A61K31/047;A61K31/13;A61K45/06 |
主分类号 |
A61K36/82 |
| 代理机构 |
|
代理人 |
Tien Hannah M. |
| 主权项 |
1. A method for treating a subject suffering from a disease or condition associated with excitotoxicity, comprising administering to the subject a therapeutically effective amount of a composition comprising memantine and a green tea polyphenol mixture in combination, wherein the ratio of the green tea polyphenol mixture and memantine is from 3:1 to 10:1, whereby the composition provides synergistic neuroprotective effect to the subject. |
| 地址 |
Taipei TW |
