Method for preparing polysaccharide nanocomposite particles and uses of the same

摘要

A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles.

主权项

1. A method for inducing cancer cell apoptosis in a subject as needed thereof, comprising administering to the subject an effective amount of a polysaccharide nanocomposite particle, wherein the polysaccharide nanocomposite particle comprises:
a core, comprising an active component selected from the group consisting of a compound of formula (I) and a pharmaceutically acceptable salt or ester of the compound, a compound of formula (II) and a pharmaceutically acceptable salt or ester of the compound, and combinations thereof:and
a carrier, derived from a polysaccharide and a cross-linking agent; wherein the carrier covers at least a part of the surface of the core; and wherein when the active component is a compound of formula (I) and/or its pharmaceutically acceptable salt or ester, the cancer cells are lung cancer cells, breast cancer cells, or rectum cancer cells.