Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists

摘要

The present invention relates to 1-aza-bicycloalkyl derivatives of formula I,;
wherein X is CH2 or a single bond; Y is a group of formula
;
and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

主权项

1. A compound of formula Iwherein
X is CH2 or a single bond; Y is a group of formulaand
R is phenyl, naphthyl, tetrahydronaphthyl, indanyl, thienyl, benzothienyl, furanyl, benzofuranyl and isobenzofuranyl, which in each case can be unsubstituted or mono-, di- or trisubstituted by halogen, cyano, formyl, acetyl, C1-C3alkoxycarbonyl, N,N-di-(C1-C3alkyl) carbamoyl, phenyl, phenoxy, methylendioxy, ethylendioxy; or C1-C4alkyl, C2-C4alkenyl, C2-C4alkinyl or C1-C4alkoxy, which radicals themselves can be unsubstituted or mono-, di- or trisubstituted by halogen; in free base or acid addition salt form.