Method and system for treatment of neuromotor dysfunction

摘要

Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.

主权项

1. A system for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part, the system comprising:
a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part; a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area; a substantially DC signal-providing component configured to provide a direct current spinal stimulation signal at a neural spinal junction; and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal; the timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal being controlled such that a pulsed motor signal from the peripheral body part and a pulsed motor signal from the motor cortex area are substantially simultaneously present at the neural spinal junction when the neural spinal junction is being stimulated by a substantially DC signal; wherein the controller component is configured to: provide the direct current spinal stimulation signal at the neural spinal junction before the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal; subsequently provide a first pulse as a peripheral stimulation signal to effect a muscle in a distal area; provide, after a time delay after providing the first pulse, a second pulse as the peripheral stimulation signal to effect the muscle in the distal area; and provide, after another time delay after providing the first and second pulses, the pulsed motor cortex stimulation signal; said time delay and said another time delay being selected such that the motor signal from the muscle in the distal area and the pulsed motor signal from the motor cortex are substantially simultaneously present at the neural spinal junction when the neural spinal junction is being stimulated by the substantially DC signal.