协同性组成物;SYNERGISTIC COMPOSITIONS

摘要

本发明描述用于治疗糖尿病(特别是非胰岛素依赖型糖尿病(NIDDM)或第2型糖尿病)和糖尿病相关性病况的协同性组成物，其包含一或多种他汀类(statins)、或一或多种二肽醯肽酶IV(DPP IV)抑制剂、或一或多种双胍抗高血糖剂、与如式(Ia)之PPAR促效剂，及适合用于这类方法的组成物。本发明也描述这类组成物之制备。本发明也关于如式(I)之某些新颖的PPAR促效剂的盐类，制备这些新颖盐类之方法及其用途。;The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.