HUMANIZED ANTIBODY MOLECULES SPECIFICALLY BINDING TO IL-31

摘要

PROBLEM TO BE SOLVED: To provide isolated polynucleotides encoding humanized mouse anti-human IL-31 antibodies that are capable of binding to IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of IL-31.SOLUTION: Provided are isolated polynucleotides encoding the heavy and light chain of an isolated monoclonal antibody specifically binding to human IL-31 comprising heavy chain variable domain comprising amino acid residue consisting of specific sequences and light chain variable domain comprising amino acid residue consisting of specific sequences; an expression vector comprising the polynucleotides; a recombinant host cell comprising the expression vector; and a method for the monoclonal antibody that comprises culturing the host cell comprising a host cell comprising said vector under conditions where the expressed heavy chain and light chain form a monoclonal antibody. In the polynucleotides, the monoclonal antibody has human Fc domain.