ENTEROBACTIN CONJUGATES AND USES THEREOF

摘要

The present invention provides novel enterobactin-cargo conjugates, such as compounds of Formula (I), and salts thereof, where X is the cargo and may be an antibiotic, a fluorophore, or biotin. The present invention also provides complexes, compositions, kits, and methods that involve the compounds of Formula (I) and are useful in delivering a cargo to a bacterium, treating a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, preventing a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, inhibiting the growth of or killing a bacterium, or determining the concentration of a bacterium in a biological sample. In certain embodiments, the bacterium is a Gram-negative bacterium.;

主权项

1. A compound of Formula (I): or a salt thereof, wherein:
each instance of L is independently a bond or a divalent linker;one instance of X is an antibiotic, a fluorophore, or a biotin moiety of the formula: all other instances of X are independently selected from the group consisting of hydrogen, an antibiotic, a fluorophore, and a biotin moiety of the formula: one instance of n is 1, 2, or 3; andthe other two instances of n are independently 0, 1, 2, or 3.