摘要 |
<p>The invention relates to peptides and peptidomimetics useful for reducing the neurotoxicity of amyloid peptide aggregates or prion-like (prionoid) protein aggregates, the invention further relates to pharmaceutical compositions containing said peptides and/or peptidomimetics, to the use of said peptides and/or peptidomimetics in the manufacture of medicines useful for the prophylaxis or treatment of diseases that can be cured by protection against the detrimental effect of Αβ-peptides /abnormal Αβ aggregation leading to amyloid plaque formation, and it relates to the use of said peptides and/or peptidomimetics in the prophylaxis or treatment of the above mentioned diseases. The invention aimed at developing treatments of neurodegenerative diseases, particularly Alzheimer's disease (AD), during which accumulation of misfolded and/or aggregated proteins occurs.</p> |
申请人 |
SZEGEDI TUDOMANYEGYETEM |
发明人 |
FÜLÖP, LÍVIA;PENKE, BOTOND;ZARÁNDI, MÁRTA;BOZSÓ, ZSOLT;VIRÓK, DEZSÖ;JANÁKY, TAMÁS;VERDIER, YANN;DATKI, ZSOLT;SZEGEDI, VIKTOR;BUSA-FEKETE, RÓBERT;SOÓS, KATALIN;KASZA, ÁGNES;KOCSOR, ANDRÁS;BORBÉLY, ERMÖKE |