发明名称 |
A method of detecting methylation |
摘要 |
The present invention relates to a method of screening for the presence of methylated DNA in a biological sample by using multiple methylation-sensitive restriction endonucleases. More particularly, the present invention relates to a method of quantitatively screening for the level of one or more methylated genes of interest without the requirement that an undigested internal reference sample is used as a point of reference against which relative quantification is calculated. The present invention is useful in a range of applications including, but not limited to, providing a simpler and more accurate means to determine DNA methylation status, such as in the context of diagnosing or monitoring conditions characterised by changes to DNA methylation. |
申请公布号 |
AU2013350330(A1) |
申请公布日期 |
2015.04.16 |
申请号 |
AU20130350330 |
申请日期 |
2013.11.26 |
申请人 |
CLINICAL GENOMICS PTY LTD |
发明人 |
MCEVOY, AIDAN;PEDERSEN, SUSANNE;BAKER, ROHAN |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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