摘要 |
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARIFSON, PAUL;CLARK, MICHAEL P.;BANDARAGE, UPUL K.;BETHIEL, RANDY S.;COURT, JOHN J.;DENG, HONGBO;DRUTU, IOANA;DUFFY, JOHN P.;FARMER, LUC;GAO, HUAI;GU, WENXIN;JACOBS, DYLAN H.;KENNEDY, JOSEPH M.;LEDEBOER, MARK W.;LEDFORD, BRIAN;MALTAIS, FRANCOIS;PEROLA, EMANUELE;WANG, TIANSHENG;WANNAMAKER, M WOODS;BYRN, RANDAL;ZHOU, YI;LIN, CHAO;JIANG, MIN;JONES, STEVEN;GERMANN, URSULA A.;SALITURO, FRANCESCO G.;KWONG, ANN DAK-YEE |