| 摘要 |
<p>The present invention relates to a novel lipoic acid/4-amino benzyl piperidine conjugated compound in which a lipoic acid as an antioxidant is conjugated with a 4-amino benzyl piperidine derivative, and to a pharmaceutical composition and functional health food composition containing the same for preventing or treating Alzheimer′s disease and degenerative diseases. The lipoic acid/4-amino benzyl piperidine conjugated compound according to the present invention exhibits activity to inhibit cholinesterase (ChE) of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and thus is an effective material in the prevention or treatment of Alzheimer′s disease and degenerative diseases. The pharmaceutical composition of the present invention contains, as an active ingredient, the lipoic acid/4-amino benzyl piperidine conjugated compound that inhibits activity of cholinesterase (ChE), and thus can be used to prevent and treat Alzheimer′s disease and degenerative diseases and can be utilized as a functional health food for alleviating Alzheimer′s disease and degenerative diseases or improving learning ability and memory power.</p> |
