| 发明名称 |
IN VITRO METHOD FOR PREDICTING DISEASE OUTCOME IN STAGE II COLORECTAL CANCER |
| 摘要 |
The present invention relates to a method for determining the likelihood of disease outcome of a patient diagnosed with microsatellite stable, stage II colorectal cancer. More in particular, the present invention relates to a method for determining the prognosis of a patient diagnosed with microsatellite stable, stage II colorectal cancer wherein the CpG island methylation status of the promoter of the CHFR gene is determined and wherein methylation of the promoter is indicative of a poor prognosis. |
| 申请公布号 |
US2015105342(A1) |
申请公布日期 |
2015.04.16 |
| 申请号 |
US201314397764 |
申请日期 |
2013.04.25 |
| 申请人 |
Universiteit Maastricht ;Academisch Ziekenhuis Maastricht ;The John Hopkins University |
发明人 |
van Engeland Manon;de Bruïne Adriaan Pieter;Herman James |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for determining the prognosis of a subject diagnosed with microsatellite stable, stage II colorectal cancer, the method comprising:
determining the CpG island methylation status of the promoter of the CHFR gene in the cancer, wherein methylation of the promoter is indicative of a poor prognosis. |
| 地址 |
Maastricht NL |
